Modeling and Designing Biomolecular Networks in Cells

Abstract:

This talk will cover contents or topics on modeling molecular networks
and analyzing nonlinear dynamics in cellular systems in a comprehensive
manner, in particular stressing on the aspects of systems and
engineering. Attention will be focused on deriving general theoretical
results and revealing the essential principles of biological systems
based on nonlinear dynamical and control theory. Specifically, I will
describe how to model or construct a general molecular network in a
single cell, how to construct a molecular network with specific
functions or structures, such as gene switching networks and gene
oscillating networks in individual cells at the molecular level, and how
to model a general multi-cellular system with the consideration of
external fluctuations and intercellular coupling of signal bio-molecules,
how to design a bio-molecular network from forward engineering viewpoint,
and how to analyze and further control the nonlinear phenomena of living
organisms at the molecular level, such as switching behaviors,
cooperative dynamics or synchronization of biological oscillators in
multi-cellular systems.